With Knight Initiative support, Stanford researchers uncover a biochemical “off-ramp” in ketosis, rewriting our understanding of how ketosis influences metabolism.
This week on From Our Neurons to Yours, we talk with Stanford neurologist Mike Greicius about his critique of new amyloid-clearing Alzheimer's drugs, and his optimism for the next wave of therapies currently in development.
Psychedelics profoundly alter human consciousness through activation of 5-HT2A receptor proteins in the brain. This team aims to develop a molecular probe to permanently illuminate 5-HT2A receptors without modifying their function or expression, allowing scientists to better study the effects of psychedelics on these receptors.
RNA sensors are a cutting edge tool in synthetic biology for probing complex molecular pathways and creating “smart” molecular circuits in cells. This team leverages state-of-the-art synthetic biology tools to understand how oligodendrocytes contribute to Alzheimer’s disease and other demyelinating disorders.
The cerebrospinal fluid (CSF) influences the development, maturation, and aging of the nervous system in ways that are not fully understood. TurboID, a synthetically engineered enzyme, can label CSF proteins to track their sources and development, providing insight into the roles the CSF plays in development, health, and disease.
A team of neuroscientists at the Knight Initiative for Brain Resilience have zeroed in on a critical regulator of brain metabolism that may be over-activated in the brains of patients with Alzheimer’s disease.
Pro-inflammatory protein TREM1 in peripheral immune cells may promote age-related cognitive decline and dementia, according to Knight Initiative–funded research.
Recent research supported by the Knight Initiative has identified a link between lipid droplets in the microglia to a known genetic risk factor for AD.
Two new studies supported by the Knight Initiative highlight groundbreaking new early biomarkers for the diagnosis and treatment of neurodegenerative disease.
This week, we sit down with neuroscientist Tony Wyss-Coray to learn about how some of your organs may be aging faster than the rest of you.