Knight Initiative News

Displaying 20 news posts of 104

1. Podcast episodes Stimulating the brain with sound

   This week on the podcast, Stanford radiology faculty Kim Butts Pauly and Raag Airan help us dive deep into the brain with focused ultrasound

   Mar 20 2025

   • Circuits and systems
   • Technology development
   • Brain function

   

2. Podcast episodes Does good sleep insulate the brain against Alzheimer's?

   This week on the podcast, Stanford psychiatry professor Erin Gibson joins us again to share the latest findings on sleep, myelin, and neurodegenerative disease.

   Mar 6 2025

   • Molecules and cells
   • Clinical / translational research
   • Brain aging

   

3. Stanford Report Changes in brain’s "sugar shield" could be key to understanding effects of aging

   New findings about the sugary armor on the brain’s frontline cells could shed light on cognitive decline and diseases like Alzheimer’s—and open new avenues for treatment.

    

   Feb 26 2025

   • Molecules and cells
   • Discovery science
   • Brain aging

   

4. Awards and honors Meet the 2025 Neurosciences Postdoctoral Scholars

   How does the brain wire itself for learning? What molecular mechanisms protect neural circuits during aging? These are just some of the research projects by the 2025 Neurosciences Postdoctoral Scholars.

   Feb 19 2025

   

5. Researcher profiles Q&A: Unraveling the role of endocannabinoid metabolism in brain aging

   Research supported by a Knight Initiative Catalyst Grant explores whether targeting pathways related to the brain’s “chill-out” system could restore youthful resilience and improve cognitive function.

   Jan 27 2025

   • Brain resilience

   

6. Stanford Medicine Magazine Sweet insight into memory

   What if forgetfulness didn't ahve to be a part of aging? Now, discoveries about the impact of glucose in mouse brains by Knight Initiative affiliate, Anne Brunet, and team suggest routes for eliciting new neuron growth in old brains.

   Jan 23 2025

   • Brain aging

   

7. Research news Blight or Benefit: How Cellular Neighbors Shape the Aging Brain

   Researchers at Stanford’s Knight Initiative for Brain Resilience merge spatial transcriptomics and AI to uncover how local cellular interactions drive brain aging and resilience

   Dec 19 2024

   • Brain resilience
   • Discovery science

   

8. Nature Synthetic GPCRs for programmable sensing and control of cell behaviour

   Kalogriopoulos NA, Tei R, Yan Y, Klein PM, Ravalin M, Cai B, Soltesz I, Li Y, Ting A.

   Dec 4 2024

   

9. Washington Post Inside your body, aging unfolds at remarkably different rates

   New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.

   Nov 25 2024

   

10. Research news Unlocking the secrets of ketosis

    With Knight Initiative support, Stanford researchers uncover a biochemical “off-ramp” in ketosis, rewriting our understanding of how ketosis influences metabolism.

    Nov 12 2024

    • Molecules and cells
    • Brain function
    • Clinical / translational research

    

11. cell A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites

    Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, Raun SH, Zhao M, Coassolo L, Islam H, Oliveira B, Dai Y, Spaas J, Delgado-Gonzalez A, Donoso K, Alvarez-Buylla A, Franco-Montalban F, Letian A, Ward CP, Liu L, Svensson KJ, Goldberg EL, Gardner CD, Little JP, Banik SM, Xu Y, Long JZ.

    Nov 4 2024

    

12. biorxiv Thalamic integration of basal ganglia and cerebellar circuits during motor learning

    Roth RH, Muniak MA, Huang CJ, Hwang FJ, Sun Y, Min C, Mao T, Ding JB.

    Nov 1 2024

    

13. biorxiv In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET

    Held RG, Liang J, Esquivies L, Khan YA, Wang C, Azubel M, Brunger AT.

    Oct 22 2024

    

14. biorxiv Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder

    Ghoochani A, Heiby JC, Rawat ES, Medoh UN, Di Fraia D, Dong W, Gastou M, Nyame K, Laqtom NN, Gomez-Ospina N, Ori A, Abu-Remaileh M.

    Oct 15 2024

    

15. Knight Initiative news Advancing Brain Resilience: 2024 Catalyst and Pilot Grant Awards

    The Knight Initiative for Brain Resilience supports 14 high-risk, high-reward projects to advance brain health and resilience research, fostering bold research across various scientific disciplines.

    Sep 18 2024

    

16. Podcast episodes Why new Alzheimer's drugs may not work for patients

    This week on From Our Neurons to Yours, we talk with Stanford neurologist Mike Greicius about his critique of new amyloid-clearing Alzheimer's drugs, and his optimism for the next wave of therapies currently in development.

    Sep 12 2024

    • Molecules and cells
    • Clinical / translational research
    • Brain aging

    

17. biorxiv A secondary β-hydroxybutyrate metabolic pathway linked to energy balance

    Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, Raun SH, Zhao M, Coassolo L, Islam H, Oliveira B, Dai Y, Spaas J, Delgado-Gonzalez A, Donoso K, Alvarez-Buylla A, Franco-Montalban F, Letian A, Ward C, Liu L, Svensson KJ, Goldberg EL, Gardner CD, Little JP, Banik SM, Xu Y, Long JZ.

    Sep 9 2024

    

18. NPR This metabolic brain boost revives memory in Alzheimer’s mice

    Study in mice, supported by the Knight Initiative, suggests that an experimental cancer drug boosted brain metabolism, restored memory, and improved Alzheimer's symptoms. This novel approach may offer a new way to treat Alzheimer's beyond targeting amyloid plaques.

    Sep 2 2024

    • Brain aging
    • Clinical / translational research

    

19. Neuroscience News Blocking a Brain Pathway Reverses Memory Loss in Alzheimer’s

    Blocking the kynurenine pathway, a regulator of brain metabolism, can restore cognitive function in lab mice with Alzheimer’s disease. The pathway is overactivated in Alzheimer’s, disrupting glucose metabolism and starving neurons of energy.

    Aug 25 2024

    

20. Science Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies

    Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI.

    Aug 23 2024