We’re unlocking the mysteries of lifelong brain resilience

Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia.

Featured 01 / 04

Knight Initiative Fall 2025 Symposium
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Under the Lights: What Surgery Reveals About Brain Resilience
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Fueling the next phase of brain resilience: 2025 Catalyst Momentum Awards
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Alzheimer's "resilience signature" predicts who will develop dementia—and how fast
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Our collaborative approach to brain resilience research is unlike any institution in the world.

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Brain Resilience Lab

Our research lab blends the innovation of a startup with the academic rigor and support of Stanford University, driving breakthroughs in healthy brain aging.
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Grants & Training Programs

Uniting scientists across disciplines to catalyze bold advances in the science of neurodegeneration, aging, and resilience.
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Resource Hub

Leveraging advanced tools in sequencing, spatial transcriptomics, and proteomics, we’re building a global library of brain aging datasets, empowering researchers to drive their own studies and advance collective knowledge on brain resilience.
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Brain Omics Central

Offering access to advanced omics technologies, including sequencing, spatial, and proteomics, alongside a growing brain tissue repository.

Upcoming Events
Join us to learn about exciting developments in brain resilience research.

Knight Initiative Events / Seminar Brain Resilience Seminar: Jacob Simon and Joe Winer

Sep 8 2025, 12:00 pm – 1:00 pm
Knight Initiative Events / Seminar Brain Resilience Seminar: Kristy Zera and Carla Shatz

Oct 6 2025, 12:00 pm – 1:00 pm

Knight Initiative news Knight Initiative symposium charts new frontiers in brain health

Knight Initiative-funded research ran the gamut from chemistry to public health, but one theme brought it all together: Studying what makes the brain resilient will help more people live better lives.
Jul 15 2025

Brain resilience

Brain aging

Clinical / translational research
Time Your brain reveals a lot about your age

Knight Initiative researchers developed a blood test that track the biological age of the brain and other organs.
Jul 10 2025
Stanford H&S Foundational research on brain development may help prevent degeneration

Stanford neurobiologist Carla Shatz, famous for discovering how neural connections develop early in life, is using that knowledge to work on the problem of how they can later deteriorate from Alzheimer’s disease.
Jul 10 2025

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