We’re unlocking the mysteries of lifelong brain resilience

Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia.

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Publications
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Meet the 2025 Neurosciences Postdoctoral Scholars
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Q&A: Unraveling the role of endocannabinoid metabolism in brain aging
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Advancing Brain Resilience: 2024 Catalyst and Pilot Grant Awards
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Our collaborative approach to brain resilience research is unlike any institution in the world.

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Brain Resilience Lab

Our research lab blends the innovation of a startup with the academic rigor and support of Stanford University, driving breakthroughs in healthy brain aging.
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Grants & Training Programs

Uniting scientists across disciplines to catalyze bold advances in the science of neurodegeneration, aging, and resilience.
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Resource Hub

Leveraging advanced tools in sequencing, spatial transcriptomics, and proteomics, we’re building a global library of brain aging datasets, empowering researchers to drive their own studies and advance collective knowledge on brain resilience.
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Brain Omics Central

Offering access to advanced omics technologies, including sequencing, spatial, and proteomics, alongside a growing brain tissue repository.

Upcoming Events
Join us to learn about exciting developments in brain resilience research.

Knight Initiative Events / Seminar Brain Resilience Seminar: Hannah Ennerfelt and Jintao Sheng

Jun 2 2025, 12:00 pm – 1:00 pm
Knight Initiative Events / Seminar Aging Research Seminar: Tanya T. Paull

Jun 9 2025, 12:00 pm – 1:00 pm

Knight Initiative News

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Podcast episodes The secrets of resilient aging

In which Anthony Wagner and Beth Mormino share what they are learning from the Stanford Aging and Memory Study about the nature of healthy brain aging.
May 15 2025

Brain aging

Clinical / translational research

Circuits and systems
Research news Alzheimer's "resilience signature" predicts who will develop dementia—and how fast

Knight Initiative researchers discover a biomarker in spinal fluid that could help forecast Alzheimer’s progression and improve clinical trials.
May 14 2025

Discovery science

Brain aging
Stanford Engineering Fixing cellular recycling centers may help treat neurodegenerative diseases

Improving cells’ ability to sort and recycle components—including cholesterol—could lead to therapies for a wide range of neurodegenerative conditions, according to research supported by the Knight Initiative for Brain Resilience and Wu Tsai Neurosciences Institute
May 7 2025

Brain aging

Clinical / translational research

Molecules and cells

Featured Projects

Innovation Awards | 2022 Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience
Lead Researcher(s)

Jonathan Z. Long
Team Members

Thomas Montine, MD, PhD

Steven Banik
Research Keywords

Brain resilience

Discovery science
Innovation Awards | 2022 Mutant microglia and resilience to Alzheimer’s disease
Lead Researcher(s)

Siddhartha Jaiswal
Team Members

Marius Wernig

Jody Elizabeth Hooper

Caleb Lareau
Research Keywords

Brain resilience

Discovery science

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