We’re unlocking the mysteries of lifelong brain resilience Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia. Our Research Featured articles Featured 01 / 04 Knight Initiative Spring 2026 Symposium Read More Preventing Parkinson’s, a new Alzheimer’s drug, and more featured at tenth Knight Initiative Symposium Read More Aging brains pile up damaged proteins Read More A new atlas could help guide researchers studying neurological disease Read More Our collaborative approach to brain resilience research is unlike any institution in the world. Upcoming EventsJoin us to learn about exciting developments in brain resilience research. Seminar Brain Resilience Seminar: Caitlin Taylor and Xiqian Jiang May 4 2026, 12:00 pm – 1:00 pm Symposium Knight Initiative Spring 2026 Symposium May 12 2026, 12:30 pm – 6:00 pm Knight Initiative News View All News The New York Times 6 Common Medications That May Lower Your Dementia Risk Shingles vaccines appear to have a protective benefit, Knight Initiative researcher Pascal Geldsetzer has shown. Apr 20 2026 Brain aging Behavior and society Clinical / translational research Podcast episodes Could Parkinson's start in the gut? We talk with neurologist Kathleen Poston about early signs of Parkinson's outside the brain and how they might influence treatment and detection Apr 16 2026 Brain aging Brain resilience Clinical / translational research HealthDay What sea creatures reveal about how fast people age Researchers who videotaped every moment in the lives of 81 African turquoise killfish gleaned intriguing insights into the aging process that may also apply to humans Apr 6 2026 Featured Projects Innovation Awards | 2022 Mutant microglia and resilience to Alzheimer’s disease Funded Researcher(s) Siddhartha Jaiswal Marius Wernig Jody Elizabeth Hooper Caleb Lareau Research Keywords Brain resilience Discovery science Innovation Awards | 2022 Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience Funded Researcher(s) Jonathan Z. Long Thomas Montine, MD, PhD Steven Banik Research Keywords Brain resilience Discovery science
Preventing Parkinson’s, a new Alzheimer’s drug, and more featured at tenth Knight Initiative Symposium Read More
The New York Times 6 Common Medications That May Lower Your Dementia Risk Shingles vaccines appear to have a protective benefit, Knight Initiative researcher Pascal Geldsetzer has shown. Apr 20 2026 Brain aging Behavior and society Clinical / translational research
Podcast episodes Could Parkinson's start in the gut? We talk with neurologist Kathleen Poston about early signs of Parkinson's outside the brain and how they might influence treatment and detection Apr 16 2026 Brain aging Brain resilience Clinical / translational research
HealthDay What sea creatures reveal about how fast people age Researchers who videotaped every moment in the lives of 81 African turquoise killfish gleaned intriguing insights into the aging process that may also apply to humans Apr 6 2026
Innovation Awards | 2022 Mutant microglia and resilience to Alzheimer’s disease Funded Researcher(s) Siddhartha Jaiswal Marius Wernig Jody Elizabeth Hooper Caleb Lareau Research Keywords Brain resilience Discovery science
Innovation Awards | 2022 Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience Funded Researcher(s) Jonathan Z. Long Thomas Montine, MD, PhD Steven Banik Research Keywords Brain resilience Discovery science