Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

Cell An emergent disease-associated motor neuron state precedes cell death in ALS

Olivia Gautier, Jacob A Blum, Thao P Nguyen, Shaolong Cao, Sandy Klemm, Mai Yamakawa, Dann Huh, Jessica A Hurt, Nasa Sinnott-Armstrong, Yi Zeng, Chung-Ha O Davis, Juliane Bombosch, Chang Liu, Lisa N Encarnacion, Kevin A Guttenplan, Derek Chen, Arwa Kathiria, Luke Zhao, Stephen Moore, Alex Meng, Kailee Ong, Don W Cleveland, John Ravits, Jessica E Rexach, William J Greenleaf, Aaron D Gitler,
Date

Jun 23, 2026
Annual Review of Biochemistry Lactate as a Chemical Modification on Proteins and Metabolites

Shuke Xiao, Andrew L Markhard, Jonathan Z Long,
Date

Jun 22, 2026
Nature Medicine Why large-scale randomized trials of live-attenuated shingles vaccination for dementia prevention are urgently needed

Pascal Geldsetzer,
Date

Jun 17, 2026
Nature Medicine Plasma proteomic signatures of cellular aging predict human disease

Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen, James W Groves, Róbert Pálovics, Daisuke Masuda, Amelia Farinas, Hamilton Se-Hwee Oh, Viktoria Wagner, Nannan Lu, Global Neurodegeneration Proteomics Consortium (GNPC), Carlos Cruchaga, Alina Isakova, Jonathan M Schott, Tony Wyss-Coray,
Date

Jun 15, 2026
Science Translational Medicine Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

Caiwei Guo, Kuchuan Chen, Sarat Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell, Shannon Zhen, Shila Mekhoubad, Ryan D Morrie, Georgiana Miller, Dragana Ilic, Moritz Boll, Euan Parnell, Peter Penzes, Noa Lipstein, Eric M Green, Leonard Petrucelli, William W Seeley, Aaron D Gitler,
Date

Jun 3, 2026
Journal of Translational Medicine Taming the "death receptor": translating the first-in-class p75^NTR modulator LM11A-31 from basic biology, across broad preclinical models, to clinical proof-of-concept

Vanessa F Langness, Danielle A Simmons, Sukhneet Kaur, Stephen M Massa, Frank M Longo,
Date

May 29, 2026
PNAS: Proceedings of the National Academy of Sciences Illuminating proinflammatory myeloid cells with PET tracers targeting GPR84

Mausam Kalita, Renesmee C Kuo, Valentina Straniero, Samantha T Reyes, Mallesh Pandrala, Alessia Lanzini, Sara Marsango, Desiree D'Moore, Piper Mahn, Andrew Setiadi, Mira Sundar, Spencer Mak, Sydney Nagy, Israt S Alam, Poorva Jain, Grace Inay, Rim Malek, Allen F Brooks, Corinne Beinat, Ermanno Valoti, Peter J H Scott, Graeme Milligan, Michelle L James,
Date

May 21, 2026
Nature Chemistry Decoding stereospecific metabolic regulation of protein modifications

Shuling Xu, Lingjun Li, Zhijun Zhu,
Date

May 20, 2026
Research Square Plasma proteomics link menopause timing to brain aging and dementia risk

Madeline Wood Alexander, Brendan Wood, Hamilton See-Hwee Oh, Veronica Augustina Bot, Julia Borger, Francesca Galbiati, Keenan A Walker, Susan M Resnick, Heather M Ochs-Balcom, Tony Wyss-Coray, Charles Kooperberg, Alexander P Reiner, Emily G Jacobs, Jennifer S Rabin, Kaitlin B Casaletto, Rowan Saloner,
Date

May 18, 2026
bioRxiv (preprint – not peer reviewed) A Perturb-seq screen guided by species divergence uncovers pathways for collateral artery formation

Xiaochen Fan, Ronghao Zhou, Brian C Raftrey, Pamela E Rios Coronado, Emily Trimm, Erin Clancy, Xinhong Chen, Jamie Bozeman, Maggie S Chen, Shoxruxxon Alimukhamedov, Juan Alcocer, Idalina Bonham, Stuti Agarwal, Alina Isakova, Vinicio A de Jesus Perez, Chong Y Park, Timothy F Shay, Viviana Gradinaru, Thomas Quertermous, Jesse M Engreitz, Kristy Red-Horse,
Date

May 18, 2026