Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

bioRxiv : the preprint server for biology Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevity

Hamilton Se-Hwee Oh, Yann Le Guen, Nimrod Rappoport, Deniz Yagmur Urey, Jarod Rutledge, Anne Brunet, Michael D Greicius, Tony Wyss-Coray
Date

Jun 25 2024
bioRxiv : the preprint server for biology Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning

Omar Jáidar, Eddy Albarran, Eli Nathan Albarran, Yu-Wei Wu, Jun B Ding
Date

Jun 19 2024
Related News

Rethinking how we learn to move in the world
Alzheimer's & dementia : the journal of the Alzheimer's Association A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model

Amira Latif-Hernandez, Tao Yang, Robert R Butler, Patricia Moran Losada, Paras S Minhas, Halle White, Kevin C Tran, Harry Liu, Danielle A Simmons, Vanessa Langness, Katrin I Andreasson, Tony Wyss-Coray, Frank M Longo
Date

May 23 2024
bioRxiv : the preprint server for biology A PTER-dependent pathway of taurine metabolism linked to energy balance

Wei Wei, Xuchao Lyu, Andrew L Markhard, Sipei Fu, Rachel E Mardjuki, Peter E Cavanagh, Xianfeng Zeng, Jakub Rajniak, Nannan Lu, Shuke Xiao, Meng Zhao, Maria Dolores Moya-Garzon, Steven D Truong, Jonathan Chiu-Chun Chou, Lianna W Wat, Saranya Chidambaranathan-Reghupaty, Laetitia Coassolo, Duo Xu, Fangfang Shen, Wentao Huang, Cuauhtemoc B Ramirez, Cholsoon Jang, Katrin J Svensson, Michael A Fischbach, Jonathan Z Long
Date

Apr 2 2024
Nature Neuroscience TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

Edward N Wilson, Congcong Wang, Michelle S Swarovski, Kristy A Zera, Hannah E Ennerfelt, Qian Wang, Aisling Chaney, Esha Gauba, Javier A Ramos Benitez, Yann Le Guen, Paras S Minhas, Maharshi Panchal, Yuting J Tan, Eran Blacher, Chinyere A Iweka, Haley Cropper, Poorva Jain, Qingkun Liu, Swapnil S Mehta, Abigail J Zuckerman, Matthew Xin, Jacob Umans, Jolie Huang, Aarooran S Durairaj, Geidy E Serrano, Thomas G Beach, Michael D Greicius, Michelle L James, Marion S Buckwalter, Melanie R McReynolds, Joshua D Rabinowitz, Katrin I Andreasson
Date

Mar 28 2024
Related Project

From gut to brain: reprogramming peripheral macrophages at the intestinal barrier to prevent age-associated inflammation and cognitive decline
Related News

Research links age-related inflammation, microglia and Alzheimer’s Disease

Is Alzheimer's an energy crisis in the brain?
Nature APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia

Michael S Haney, Róbert Pálovics, Christy Nicole Munson, Chris Long, Patrik K Johansson, Oscar Yip, Wentao Dong, Eshaan Rawat, Elizabeth West, Johannes C M Schlachetzki, Andy Tsai, Ian Hunter Guldner, Bhawika S Lamichhane, Amanda Smith, Nicholas Schaum, Kruti Calcuttawala, Andrew Shin, Yung-Hua Wang, Chengzhong Wang, Nicole Koutsodendris, Geidy E Serrano, Thomas G Beach, Eric M Reiman, Christopher K Glass, Monther Abu-Remaileh, Annika Enejder, Yadong Huang, Tony Wyss-Coray
Date

Mar 14 2024
Acta neuropathologica Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease

Jarod Rutledge, Benoit Lehallier, Pardis Zarifkar, Patricia Moran Losada, Marian Shahid-Besanti, Dan Western, Priyanka Gorijala, Sephira Ryman, Maya Yutsis, Gayle K Deutsch, Elizabeth Mormino, Alexandra Trelle, Anthony D Wagner, Geoffrey A Kerchner, Lu Tian, Carlos Cruchaga, Victor W Henderson, Thomas J Montine, Per Borghammer, Tony Wyss-Coray, Kathleen L Poston
Date

Mar 12 2024
Molecular cell Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease

Kwamina Nyame, Andy Hims, Aya Aburous, Nouf N Laqtom, Wentao Dong, Uche N Medoh, Julia C Heiby, Jian Xiong, Alessandro Ori, Monther Abu-Remaileh
Date

Mar 6 2024
Related Project
Annals of clinical and translational neurology Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer's disease spectra

Melanie J Plastini, Carla Abdelnour, Christina B Young, Edward N Wilson, Marian Shahid-Besanti, Jennifer Lamoureux, Katrin I Andreasson, Geoffrey A Kerchner, Thomas J Montine, Victor W Henderson, Kathleen L Poston
Date

Mar 4 2024
Alzheimer's & dementia : the journal of the Alzheimer's Association Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes

Olamide Abiose, Jarod Rutledge, Patricia Moran-Losada, Michael E Belloy, Edward N Wilson, Zihuai He, Alexandra N Trelle, Divya Channappa, America Romero, Jennifer Park, Maya V Yutsis, Sharon J Sha, Katrin I Andreasson, Kathleen L Poston, Victor W Henderson, Anthony D Wagner, Tony Wyss-Coray, Elizabeth C Mormino
Date

Dec 26 2023