Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association Comparison of amyloid PET acquired through standardized and unstandardized protocols

Karly A Cody, Andrzej Sokolowski, Lucah Medina Guerra, Philip S Insel, William J Jagust, Theresa M Harrison, Elizabeth C Mormino
Date

Sep 22 2025
PNAS C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer’s disease and mediates synapse pruning

Barbara K. Brott, Aram J. Raissi, Kristina D. Micheva, Jost Vielmetter, Monique S. Mendes, Caroline J. Baccus, Jolie Huang, and Carla J. Shatz
Date

Sep 18 2025
Related Project

Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's disease
medRxiv : the preprint server for health sciences Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity

James W Groves, Veronica Augustina Bot, Daisy Yi Ding, Jennifer Nicholas, Amelia Farinas, Hamilton See-Oh, Sarah-Naomi James, Andrew Wong, Dylan M Williams, Josh King-Robson, Nishi Chaturvedi, Marcus Richards, Tony Wyss-Coray, Jonathan M Schott
Date

Sep 18 2025
Nature metabolism Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice

Hailan Liu, Veronica L Li, Qingzhuo Liu, Yao Liu, Cunjin Su, Hueyxian Wong, Na Yin, Hesong Liu, Xing Fang, Kristine M McDermott, Hueyzhong Wong, Meng Yu, Longlong Tu, Jonathan C Bean, Yongxiang Li, Mengjie Wang, Yue Deng, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Junying Han, Megan E Burt, Sanika V Jossy, Chunmei Wang, Yongjie Yang, Benjamin R Arenkiel, Dong Kong, Yang He, Jonathan Z Long, Yong Xu
Date

Sep 16 2025
Bio-protocol Isolation and Imaging of Microvessels From Brain Tissue

Josephine K Buff, Carolyn R Bertozzi, Tony Wyss-Coray, Sophia M Shi
Date

Sep 15 2025
bioRxiv : the preprint server for biology Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

Caiwei Guo, Kuchuan Chen, Sarat C Vatsavayai, Tetsuya Akiyama, Yi Zeng, Chang Liu, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell, Shannon Zhen, Shila Mekhoubad, Ryan D Morrie, Georgiana Miller, Eric M Green, Leonard Petrucelli, William W Seeley, Aaron D Gitler
Date

Sep 15 2025
Cell reports Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning

Omar Jáidar, Eddy Albarran, Eli Nathan Albarran, Yu-Wei Wu, Jun B Ding
Date

Sep 6 2025
Related Project

Preserving motor engrams in Parkinson's disease: Neural circuit and transcriptomic studies and strategies for resilient motor control
Related News

Rethinking how we learn to move in the world
bioRxiv : the preprint server for biology An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS

Olivia Gautier, Jacob A Blum, Thao P Nguyen, Sandy Klemm, Mai Yamakawa, Nasa Sinnott-Armstrong, Yi Zeng, Chung-Ha O Davis, Juliane Bombosch, Lisa Nakayama, Kevin A Guttenplan, Derek Chen, Arwa Kathira, Luke Zhao, Jessica E Rexach, William J Greenleaf, Aaron D Gitler
Date

Sep 5 2025
Related Project

Elucidating the role of alternative polyadenylation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
bioRxiv : the preprint server for biology Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease

Matthias Flotho, Andrew Yang, Fabian Kern, Simon Graf, Ian Ferenc Diks, Heather Shin, Kristy A Zera, Daniela Berdnik, Maayan R Agam, Divya Channappa, Sophia M Shi, Malia Alexandra Belnap, Epiphani C Simmons, Karen Bradshaw, Friederike Grandke, David A Bennett, Marion Buckwalter, Andreas Keller, Tony Wyss-Coray
Date

Sep 5 2025
JAMA neurology Concurrent Changes in Plasma Phosphorylated Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease

Philip S Insel, Niklas Mattsson-Carlgren, Oliver Langford, Vincent M Caruso, Antoine Leuzy, Christina B Young, Adam Boxer, Paul S Aisen, Reisa A Sperling, Elizabeth C Mormino, Michael C Donohue
Date

Aug 25 2025