Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

bioRxiv : the preprint server for biology An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS

Olivia Gautier, Jacob A Blum, Thao P Nguyen, Sandy Klemm, Mai Yamakawa, Nasa Sinnott-Armstrong, Yi Zeng, Chung-Ha O Davis, Juliane Bombosch, Lisa Nakayama, Kevin A Guttenplan, Derek Chen, Arwa Kathira, Luke Zhao, Jessica E Rexach, William J Greenleaf, Aaron D Gitler
Date

Sep 5 2025
bioRxiv : the preprint server for biology Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease

Matthias Flotho, Andrew Yang, Fabian Kern, Simon Graf, Ian Ferenc Diks, Heather Shin, Kristy A Zera, Daniela Berdnik, Maayan R Agam, Divya Channappa, Sophia M Shi, Malia Alexandra Belnap, Epiphani C Simmons, Karen Bradshaw, Friederike Grandke, David A Bennett, Marion Buckwalter, Andreas Keller, Tony Wyss-Coray
Date

Sep 5 2025
JAMA neurology Concurrent Changes in Plasma Phosphorylated Tau 217, Tau PET, and Cognition in Preclinical Alzheimer Disease

Philip S Insel, Niklas Mattsson-Carlgren, Oliver Langford, Vincent M Caruso, Antoine Leuzy, Christina B Young, Adam Boxer, Paul S Aisen, Reisa A Sperling, Elizabeth C Mormino, Michael C Donohue
Date

Aug 25 2025
Parkinsonism & related disorders Hope vs. Hype I: It is time to redefine and rename Parkinson disease based on alpha-synuclein

Kathleen L Poston, Camila C Piccinin, Tiago A Mestre
Date

Aug 19 2025
Alzheimer's & dementia : the journal of the Alzheimer's Association Twenty years of therapeutic development in tauopathy mouse models: a scoping review

Vanessa F Langness, Danielle A Simmons, Tyne L M McHugh, Robert R Butler, James Zhou, Harry Liu, Tao Yang, Lisa M Ellerby, Frank M Longo
Date

Aug 18 2025
bioRxiv : the preprint server for biology Motor learning drives region-specific transcriptomic remodeling in the motor cortex and dorsal striatum

Yue Sun, Richard H Roth, Fuu-Jiun Hwang, Sui Wang, Jun B Ding
Date

Aug 12 2025
Nature Therapeutic genetic restoration through allogeneic brain microglia replacement

Marius Marc-Daniel Mader, Alexa Scavetti, Yongjin Yoo, Aaron Tianyue Chai, Takeshi Uenaka & Marius Wernig
Date

Aug 6 2025
Nature chemical biology Directed evolution of LaccID for cell surface proximity labeling and electron microscopy

Song-Yi Lee, Heegwang Roh, David Gonzalez-Perez, Mason R Mackey, Daniel Hoces, Colleen N McLaughlin, Chang Lin, Stephen R Adams, Khanh Nguyen, Keun-Young Kim, David J Luginbuhl, Liqun Luo, Namrata D Udeshi, Steven A Carr, Rogelio A Hernández-López, Mark H Ellisman, Miguel Alcalde, Alice Y Ting
Date

Aug 1 2025
Nature Remodelling of corticostriatal axonal boutons during motor learning

Mengjun Sheng, Di Lu, Richard H Roth, Fuu-Jiun Hwang, Kaiwen Sheng, Jun B Ding
Date

Jul 31 2025
Related Project

Preserving motor engrams in Parkinson's disease: Neural circuit and transcriptomic studies and strategies for resilient motor control
bioRxiv : the preprint server for biology Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss

Yi Zeng, Odilia Sianto, Anastasiia Lovchykova, Chang Liu, Tetsuya Akiyama, Leonard Petrucelli, Aaron D Gitler
Date

Jul 17 2025