Publications

Research supported by Knight Initiative for Brain Resilience grants and fellowships is advancing our understanding of healthy brain aging and new approaches to combat neurodegenerative disease.

Nature Organ aging signatures in the plasma proteome track health and disease

Hamilton Se-Hwee Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Patricia Moran-Losada, Divya Channappa, Deniz Yagmur Urey, Kate Kim, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Dan Western, Menghan Liu, Pat Kohlfeld, John Budde, Edward N Wilson, Yann Guen, Taylor M Maurer, Michael Haney, Andrew C Yang, Zihuai He, Michael D Greicius, Katrin I Andreasson, Sanish Sathyan, Erica F Weiss, Sofiya Milman, Nir Barzilai, Carlos Cruchaga, Anthony D Wagner, Elizabeth Mormino, Benoit Lehallier, Victor W Henderson, Frank M Longo, Stephen B Montgomery, Tony Wyss-Coray
Date

Dec 6 2023
Nucleic acids research ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution

Matthias Flotho, Jérémy Amand, Pascal Hirsch, Friederike Grandke, Tony Wyss-Coray, Andreas Keller, Fabian Kern
Date

Nov 9 2023
Cell Atlas of the aging mouse brain reveals white matter as vulnerable foci

Oliver Hahn, Aulden G Foltz, Micaiah Atkins, Blen Kedir, Patricia Moran-Losada, Ian H Guldner, Christy Munson, Fabian Kern, Róbert Pálovics, Nannan Lu, Hui Zhang, Achint Kaur, Jacob Hull, John R Huguenard, Sebastian Grönke, Benoit Lehallier, Linda Partridge, Andreas Keller, Tony Wyss-Coray
Date

Aug 17 2023
Nature aging Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

Cana Park, Oliver Hahn, Shweta Gupta, Arturo J Moreno, Francesca Marino, Blen Kedir, Dan Wang, Saul A Villeda, Tony Wyss-Coray, Dena B Dubal
Date

Aug 16 2023
bioRxiv : the preprint server for biology APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia

Michael S Haney, Róbert Pálovics, Christy Nicole Munson, Chris Long, Patrik Johansson, Oscar Yip, Wentao Dong, Eshaan Rawat, Elizabeth West, Johannes Cm Schlachetzki, Andy Tsai, Ian Hunter Guldner, Bhawika S Lamichhane, Amanda Smith, Nicholas Schaum, Kruti Calcuttawala, Andrew Shin, Yung-Hua Wang, Chengzhong Wang, Nicole Koutsodendris, Geidy E Serrano, Thomas G Beach, Eric M Reiman, Christopher K Glass, Monther Abu-Remaileh, Annika Enejder, Yadong Huang, Tony Wyss-Coray
Date

Aug 7 2023
Nature medicine Clonal hematopoiesis is associated with protection from Alzheimer's disease

Hind Bouzid, Julia A Belk, Max Jan, Yanyan Qi, Chloé Sarnowski, Sara Wirth, Lisa Ma, Matthew R Chrostek, Herra Ahmad, Daniel Nachun, Winnie Yao, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Alexa Beiser, Alexander G Bick, Joshua C Bis, Myriam Fornage, William T Longstreth, Oscar L Lopez, Pradeep Natarajan, Bruce M Psaty, Claudia L Satizabal, Joshua Weinstock, Eric B Larson, Paul K Crane, C Dirk Keene, Sudha Seshadri, Ansuman T Satpathy, Thomas J Montine, Siddhartha Jaiswal
Date

Jun 15 2023
Nature aging An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease

Yuanbing Jiang, Xiaopu Zhou, Hiu Yi Wong, Li Ouyang, Fanny C F Ip, Vicky M N Chau, Shun-Fat Lau, Wei Wu, Daniel Y K Wong, Heukjin Seo, Wing-Yu Fu, Nicole C H Lai, Yuewen Chen, Yu Chen, Estella P S Tong, Alzheimer’s Disease Neuroimaging Initiative, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, Maryam Shoai, Benoit Lehallier, Patricia Morán Losada, Eleanor O'Brien, Tenielle Porter, Simon M Laws, John Hardy, Tony Wyss-Coray, Colin L Masters, Amy K Y Fu, Nancy Y Ip
Date

Apr 28 2023
Nature biotechnology Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

Viktoria Wagner, Fabian Kern, Oliver Hahn, Nicholas Schaum, Nicole Ludwig, Tobias Fehlmann, Annika Engel, Dominic Henn, Shusruto Rishik, Alina Isakova, Michelle Tan, Rene Sit, Norma Neff, Martin Hart, Eckart Meese, Steve Quake, Tony Wyss-Coray, Andreas Keller
Date

Apr 27 2023
bioRxiv : the preprint server for biology Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease

Ching-Chieh Chou, Ryan Vest, Miguel A Prado, Joshua Wilson-Grady, Joao A Paulo, Yohei Shibuya, Patricia Moran-Losada, Ting-Ting Lee, Jian Luo, Steven P Gygi, Jeffery W Kelly, Daniel Finley, Marius Wernig, Tony Wyss-Coray, Judith Frydman
Date

Apr 10 2023
Molecular neurodegeneration Unraveling protein dynamics to understand the brain - the next molecular frontier

Kyle D Brewer, Sophia M Shi, Tony Wyss-Coray
Date

Jun 18 2022