News | Knight Initiative for Brain Resilience

The number one thing most people fear as they age is developing dementia. As the world’s population becomes increasingly older, this is a growing public health issue too.

In searching for how a gene mutation associated with the cell’s recycling center leads to a rare disease, Knight Initiative for Brain Resilience and Wu Tsai Neuro affiliate Monther Abu-Remaileh and team identified a missing link in neurodegenerative condi

Pathologist Siddhartha Jaiswal discovers a surprising twist to our biology: age-related mutations that increase the risk of blood disease also protect against brain disease.

Funded in part by the Knight Initiative , researchers at the Wyss-Coray Lab have discovered that age-related cognitive decline is most pronounced in the brain’s white matter in a new study.

A study in mice suggests that the most pronounced changes that occur over time are in the white matter—neurons that are integral to transmitting signals across the brain. The research also examined how two anti-aging treatments—caloric restriction and inf

A study in mice finds that white matter — the tissue that transmits messages around the brain — shows the greatest changes as the animals age.

A new study demonstrating CRISPR gene editing in killifish opens the doors for ambitious research on the biological drivers of aging.

The Phil and Penny Knight Initiative for Brain Resilience is proud to announce the recipients of its inaugural 2022 Innovation and Catalyst Grants.

Tony Wyss-Coray and colleagues have turned up substances in blood that can accelerate or slow down the brain-aging clock. They've identified proteins on blood-vessel surfaces through which some of these molecules can act on the brain, despite the existenc

An international collaboration led by Michael Greicius, MD, professor of neurology at Stanford Medicine, has found a rare mutation that protects against Alzheimer’s in individuals who are genetically predisposed to the disease.

With a new study published in Nature, Wu Tsai Neurosciences Institute researchers are helping to show that the cerebrospinal fluid that bathes our brains holds clues to healthy brain aging.

Katrin Andreasson discusses how immune cells can cause harmful brain inflammation and contribute to the development of neurodegenerative diseases like Alzheimer’s disease.

A new initiative on brain resilience will study the causes of cognitive decline—what may be done to prevent, delay, or reverse the decline—and what goes right for those who keep their cognitive abilities intact.