Research supported by a Knight Initiative Catalyst Grant explores whether targeting pathways related to the brain’s “chill-out” system could restore youthful resilience and improve cognitive function.
The science to advance our understanding of the aging process—and to potentially slow it down—has made important strides. One of the leading scientists responsible for this work is Professor Tony Wyss-Coray, whose work has focused on brain aging.
A new study co-authored by Knight Initiative Director Tony Wyss-Coray demonstrates a simple way of studying organ aging by analyzing distinct proteins in blood, enabling the prediction of individuals’ risk for diseases.
It turns out that your chronological age really is just a number. What’s more important for knowing disease risk is the biological age of each of your organs.
In today’s mostly plague- and famine-free world, if you can avoid more modern scourges like gun and car violence, you can expect your death to arrive not with a bang but a whimper; when one of your organs sput-sput-sputters out.
Stanford Medicine queried Wu Tsai Neuro and Knight Initiative affiliates share their expertise on the what the human brain are thinking about humans vs AI.
Erin Gibson’s lab has discovered that the precursor cells to myelin-producing oligodendrocytes are regulated by the circadian system in mice. When that regulation breaks down, the researchers saw abnormal myelination — but also fragmented sleep.
Working in the Gibson Lab, Brain Resilience Postdoc Scholar Daniela Rojo looks at how abnormal changes in gene activity impact the cells involved in producing myelin to the extent that it leads to neurodegeneration in the brain.
The number one thing most people fear as they age is developing dementia. As the world’s population becomes increasingly older, this is a growing public health issue too.
In searching for how a gene mutation associated with the cell’s recycling center leads to a rare disease, Knight Initiative for Brain Resilience and Wu Tsai Neuro affiliate Monther Abu-Remaileh and team identified a missing link in neurodegenerative condi
Pathologist Siddhartha Jaiswal discovers a surprising twist to our biology: age-related mutations that increase the risk of blood disease also protect against brain disease.
A study in mice suggests that the most pronounced changes that occur over time are in the white matter—neurons that are integral to transmitting signals across the brain. The research also examined how two anti-aging treatments—caloric restriction and inf
Funded in part by the Knight Initiative, researchers at the Wyss-Coray Lab have discovered that age-related cognitive decline is most pronounced in the brain’s white matter in a new study.
