The database of lysosomal proteins is already helping researchers study how brain cells’ waste and recycling systems work—or don’t—in Alzheimer’s and other neurological diseases
Join us as we look back on some of the key studies we covered here at Wu Tsai Neuro and the Knight Initiative in 2025 to give a (very partial) overview of the impact of our community’s research efforts this past year
Neuroradiologist Raag Airan and his lab have found a non-invasive, drug-free method to help clean the brain, reduce inflammation, and treat disease—and with Knight Initiative for Brain Resilience support, they plan to test it in people soon.
Knight Initiative researchers are uncovering the fine points of how our brains learn to move. In the long run, their findings could help devise better treatments for Parkinson's disease.
A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging – shedding light on cognitive decline and diseases like Alzheimer’s, Parkinson’s, and ALS.
Stanford researchers reviewed over 400 therapy evaluations and discovered a crucial mismatch: Mouse studies test disease prevention, while human trials test treatment of existing disease.
Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.
Blood and cerebrospinal fluid markers tied to inflammation and metabolism sort some patients into subgroups, according to Knight Initiative researchers, a step toward predicting progression and tailoring care.
The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.
The Global Neurodegeneration Proteomics Consortium gathered a trove of data on potential signs of neurological disease—and researchers including Knight Initiative director Tony Wyss-Coray are already using it to make new discoveries.
A blood-test analysis developed at Stanford Medicine can determine the “biological ages” of 11 separate organ systems in individuals’ bodies and predict the health consequences.
Research from the Giocomo lab finds that mice create neural maps of the location of rewards, distinct from the well-known hippocampal maps of an animal's location in space.
Improving cells’ ability to sort and recycle components—including cholesterol—could lead to therapies for a wide range of neurodegenerative conditions.
A new analysis of a vaccination program in Wales by a Knight Initiative–supported team found that the shingles vaccine appeared to lower new dementia diagnoses by 20% — more than any other known intervention.
New findings about the sugary armor on the brain’s frontline cells could shed light on cognitive decline and diseases like Alzheimer’s—and open new avenues for treatment.
