Event Details:
The first Monday of each month, the Knight Initiative for Brain Resilience will host monthly seminars to bring together awardees, affiliated professors and students for a series of 'lab meeting' styled talks. Two speakers will discuss their brain resilience research, experiences in the field, and answer questions about their work.
To support our researchers' participation in this open science ‘lab-meeting style’ exchange of ideas, these seminars are not streamed/recorded and are only open to members of the Stanford community.
Peter Klein, Stanford University
Endocannabinoid metabolism as a driver of brain aging
Declining cognitive function is currently a largely unavoidable consequence that accompanies aging. Our team in the Soltesz lab now hopes to leverage earlier discoveries by our Knight Initiative collaborators in the Andreasson lab who uncovered a mechanism through which aging gut immune cells initiate cascading inflammatory signaling that impairs brain function. We hypothesized that neurons in the aging brain may release elevated levels of a class of signaling molecules known as endocannabinoids, which in turn fuel the gut inflammatory response. We have been investigating whether by preventing the link from brain endocannabinoid release to the gut we can reduce body wide inflammatory signaling and help maintain high level brain function during aging.
Scott Dixon, Stanford University
Exploring the lysosome-ferroptosis axis in cell death and degeneration
Scott's lab is interested in understanding mechanisms of non-apoptotic cell death using chemical, biochemical and genetic tools.
