Scott A. Small, MD, Columbia University
Hosted by Tony Wyss-Coray
The Pathogenicity of Endosomal Recycling in Alzheimer’s Disease and its Therapeutic Potential
Recent findings ranging from genetics to structural biology, together with studies in human neurons, animal models and patient brains, implicate the retromer-dependent endosomal recycling pathway as both causal and common in Alzheimer’s disease. In this talk, I will briefly review how the pathway was identified and validated. I will then discuss two unpublished studies that are nearing completion. The first, clarifying its pathophysiology, showing in mouse models how pathway disruptions can mediate Alzheimer’s neurodegenerative process. The second are studies that suggest novel therapeutic approaches for correcting pathway disruptions.