Shagayeg Navabpour
Postdoc fellow, Stanford University
Integrative Mental Health Laboratory (IMHL) [Duncan Lab]
Talk Title to be announced
Bio & Abstract coming soon
Scott Dixon
Prof. Scott Dixon, Department of Biology, Stanford University
Regulation of non-apoptotic cell death by disease-associated genes in the endolysosomal network
Bio
Scott is a Professor in the Department of Biology. As a postdoctoral fellow at Columbia University, he trained as a cell biologist and chemical biologist and helped discover the process of ferroptosis. His lab is currently focused on the regulation of non-apoptotic cell death in various disease contexts.
Abstract
The endolysosomal system is necessary for proper protein sorting and disposal. Mutations in various endolysosomal genes can contribute to neurological disease. We find that some of these genes, including CLN1 (PPT1) and DNAJC13, are important regulators of a novel form of non-apoptotic cell death termed lipid-dependent necrosis. I will present our latest insights into the nature of this unusual lethal mechanism and how disease-associated genes modulate cell death. Our results could help understand how these mutations contribute to cell death in the nervous system.
About the Series
The first Monday of each month, the Knight Initiative for Brain Resilience will host monthly seminars to bring together awardees, affiliated professors and students for a series of 'lab meeting' styled talks. Two speakers will discuss their brain resilience research, experiences in the field, and answer questions about their work.
To support our researchers' participation, these seminars are not streamed/recorded and are only open to members of the Stanford community.