Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer's disease through machine learning and transcriptomic integration

Alzheimer's & Dementia |

Kanhao Zhao, Hua Xie, Tovia Jacobs, Naomi L Gaggi, Juan Fortea, Nancy B Carlisle, Gregory A Fonzo, Kilian M Pohl, Ricardo S Osorio, Yu Zhang, ADNI Study Group and the PREVENT‐AD Research Group

INTRODUCTION: Functional brain network alterations associated with Alzheimer's disease (AD) pathology, including amyloid beta (Aβ) and phosphorylated tau (p-tau), are difficult to interpret due to overlapping aging-associated and non-amyloid biological processes.