Our innovation grants support creative and bold proposals to generate paradigm-shifting insights into the biology of brain aging, the drivers of neurodegenerative disease and opportunities to promote brain health and resilience long into what we now consider "old age".
Application is closed
- Applicants may request up to $1.5M in direct costs over a 3-year duration.
- Stanford faculty of any research or clinical background are encouraged to apply.
- The grant program is open to all proposals relevant to brain resilience and neurodegeneration
The Knight Initiative for Brain Resilience announces 2023 Innovation and Catalyst awards
Purpose
Time seems to chip away relentlessly at our cognitive abilities after we pass midlife, leading to what some believe is the inevitable loss of memory function and the development of dementia. An estimated 50 million people will suffer from Alzheimer's type dementia across the globe by the end of the decade, simply because modern medicine allows us to survive other causes of death. In a similar vein, as more people benefit from advances in health care and medical breakthroughs, an ever-growing number of them succumb to Parkinson’s disease, frontotemporal dementia, vascular dementia, and Lou Gehrig’s disease (ALS).
This is a sobering view of growing old and, unfortunately, most of us have family or close friends who are affected by one of these diseases — most often Alzheimer’s disease. The complexity of the problem is staggering as the brain, the central command of our body with billions of computing units (neurons) and trillions of connections (synapses), is essentially malfunctioning.
Yet, there is hope! About 1 in 10,000 individuals in wealthier nations reach 100 years of age cognitively intact – they seem to be resilient to the ravages of time. Not only do they not suffer from heart disease, diabetes, or hypertension but many of them have remarkably intact memories and brain functions! Many more people age into their nineties with perfectly working brains. What’s more, an increasing body of research finds individuals who have a genetic predisposition to develop dementia but who somehow escape this genetic fate against all odds.
What if we could emulate this seemingly successful dodging of the aging process or genetic risk factors? Or maybe even reverse aspects of brain aging in older individuals altogether, essentially rejuvenating their minds?
The Knight Initiative for Brain Resilience Innovation Grants seek the most creative and bold proposals to fundamentally shift our understanding of the brain's potential for resilience against aging and neurodegeneration — with the ultimate goal of keeping the brain healthy long into what we now consider old age.
Innovation grant projects
Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience
Exercise improves cognition and protects against age-associated neurodegenerative diseases, but further research is needed to understand exactly how this occurs. This project aims to pave the way for therapeutics that can capture the benefits of exercise for promoting brain resilience.
Manipulating inflammation in the aging brain to promote brain resilience
Inflammation is a hallmark of brain aging, yet the source of inflammation in the old brain — and how to eliminate it — is unknown. This team aims to provide insight on how inflammation affects the aging brain that could potentially lead to the generation of new therapies to promote brain resilience.
Role of Proteostasis and Organelle Homeostasis in Brain Resilience during Aging
This team aims to define how and why protein production breaks down in aging cells, leading to disease. This research may lead to new diagnostic and therapeutic approaches against neurodegenerative diseases and potentially aging itself.
Unleashing engineered T cells as disease sensors and therapeutic actuators for neurodegenerative disease
This project will explore whether amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) result from immune cells attacking altered neurons. The team aims to pioneer the use of engineered immune cells as therapies for neurodegenerative disorders.