Pro-inflammatory protein TREM1 in peripheral immune cells may promote age-related cognitive decline and dementia, according to Knight Initiative–funded research.
Recent research supported by the Knight Initiative has identified a link between lipid droplets in the microglia to a known genetic risk factor for AD.
This week, we sit down with neuroscientist Tony Wyss-Coray to learn about how some of your organs may be aging faster than the rest of you.
This week on From Our Neurons to Yours, we sit down with Stanford neurologist Kathleen Poston to learn about a sea change in our understanding of Parkinson's Disease.
Disabling the notorious APOE4 gene might protect against the disease, according to research from Michael Greicius and team.
We are proud to welcome the 2024 Neurosciences Postdoctoral Scholars — ten young scientists pursuing novel, multi-disciplinary approaches to understanding the workings of the brain.
Maintaining the health and function of the aging brain is crucial to improving the quality of older people’s lives and reducing societal burden. Aging is often accompanied by a decline in memory for life events (episodic memory), especially in those at risk for Alzheimer’s disease (AD). Yet some at-risk individuals manage to maintain memory function, which raises important questions about the brain mechanisms that underly memory resilience.
Resilience to Alzheimer’s disease describes those rare individuals who exhibit normal cognitive function while harboring a high disease burden. Better understanding of the mechanisms that confer protection against cognitive decline despite high-level AD pathology offers potential therapeutic insights for preventing dementia in AD. Recent advances in the field provide a unique opportunity to explore the spatial distribution of molecules in the human brain at an unprecedented level of detail.
The Knight Initiative for Brain Resilience will host a "lab meeting style" seminar series to bring together awardees, affiliated professors, and students. Two speakers will discuss their brain resilience research, field experience, and answer questions about their work.
The science to advance our understanding of the aging process—and to potentially slow it down—has made important strides. One of the leading scientists responsible for this work is Professor Tony Wyss-Coray, whose work has focused on brain aging.