We’re unlocking the mysteries of lifelong brain resilience

Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia.

Featured 01 / 04

Spring 2025 Symposium: Brain Resilience Research Showcase
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Advancing Brain Resilience: 2024 Catalyst and Pilot Grant Awards
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Why new Alzheimer's drugs may not work for patients
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Knight symposium highlights advances in brain resilience research
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Our collaborative approach to brain resilience research is unlike any institution in the world.

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Brain Resilience Lab

Our research lab blends the innovation of a startup with the academic rigor and support of Stanford University, driving breakthroughs in healthy brain aging.
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Grants & Training Programs

Uniting scientists across disciplines to catalyze bold advances in the science of neurodegeneration, aging, and resilience.
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Resource Hub

Leveraging advanced tools in sequencing, spatial transcriptomics, and proteomics, we’re building a global library of brain aging datasets, empowering researchers to drive their own studies and advance collective knowledge on brain resilience.
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Brain Omics Central

Offering access to advanced omics technologies, including sequencing, spatial, and proteomics, alongside a growing brain tissue repository.

Upcoming Events
Join us to learn about exciting developments in brain resilience research.

Seminar Brain Resilience Seminar: Brad Zuchero and Pascal Geldsetzer

Apr 7 2025, 12:00 pm – 1:00 pm
Knight Initiative Events / Seminar Joseph S Takahashi- Circadian clock regulation of healthspan and lifespan

Apr 14 2025, 12:00 pm – 1:00 pm

Knight Initiative News

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Podcast episodes Stimulating the brain with sound

This week on the podcast, Stanford radiology faculty Kim Butts Pauly and Raag Airan help us dive deep into the brain with focused ultrasound
Mar 20 2025

Circuits and systems

Technology development

Brain function
Podcast episodes Does good sleep insulate the brain against Alzheimer's?

This week on the podcast, Stanford psychiatry professor Erin Gibson joins us again to share the latest findings on sleep, myelin, and neurodegenerative disease.
Mar 6 2025

Molecules and cells

Clinical / translational research

Brain aging
Stanford Report Changes in brain’s "sugar shield" could be key to understanding effects of aging

New findings about the sugary armor on the brain’s frontline cells could shed light on cognitive decline and diseases like Alzheimer’s—and open new avenues for treatment.
Feb 26 2025

Molecules and cells

Discovery science

Brain aging

Featured Projects

Innovation Awards | 2022 Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience
Lead Researcher(s)

Jonathan Z. Long
Team Members

Thomas Montine, MD, PhD

Steven Banik
Research Keywords

Brain resilience

Discovery science
Innovation Awards | 2022 Mutant microglia and resilience to Alzheimer’s disease
Lead Researcher(s)

Siddhartha Jaiswal
Team Members

Marius Wernig

Jody Elizabeth Hooper

Caleb Lareau
Research Keywords

Brain resilience

Discovery science

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