We’re unlocking the mysteries of lifelong brain resilience

Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia.

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Our collaborative approach to brain resilience research is unlike any institution in the world.

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Brain Resilience Lab

Our research lab blends the innovation of a startup with the academic rigor and support of Stanford University, driving breakthroughs in healthy brain aging.
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Grants & Training Programs

Uniting scientists across disciplines to catalyze bold advances in the science of neurodegeneration, aging, and resilience.
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Resource Hub

Leveraging advanced tools in sequencing, spatial transcriptomics, and proteomics, we’re building a global library of brain aging datasets, empowering researchers to drive their own studies and advance collective knowledge on brain resilience.
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Brain Omics Central

Offering access to advanced omics technologies, including sequencing, spatial, and proteomics, alongside a growing brain tissue repository.

Upcoming Events
Join us to learn about exciting developments in brain resilience research.

Knight Initiative Events / Seminar Brain Resilience Special Seminar: Marco Prinz

Mar 3 2025, 10:00 am – 11:00 am
Knight Initiative Events / Seminar Brain Resilience Seminar: Nico van Donk and Takeshi Uenaka

Mar 3 2025, 12:00 pm – 1:00 pm

Awards and honors Meet the 2025 Neurosciences Postdoctoral Scholars

How does the brain wire itself for learning? What molecular mechanisms protect neural circuits during aging? These are just some of the research projects by the 2025 Neurosciences Postdoctoral Scholars.
Feb 19 2025
Researcher profiles Q&A: Unraveling the role of endocannabinoid metabolism in brain aging

Research supported by a Knight Initiative Catalyst Grant explores whether targeting pathways related to the brain’s “chill-out” system could restore youthful resilience and improve cognitive function.
Jan 27 2025

Brain resilience
Stanford Medicine Magazine Sweet insight into memory

What if forgetfulness didn't ahve to be a part of aging? Now, discoveries about the impact of glucose in mouse brains by Knight Initiative affiliate, Anne Brunet, and team suggest routes for eliciting new neuron growth in old brains.
Jan 23 2025

Brain aging

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