Knight Initiative for Brain Resilience

Blood and cerebrospinal fluid markers tied to inflammation and metabolism sort some patients into subgroups, according to Knight Initiative researchers, a step toward predicting progression and tailoring care.

The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.

Fat-filled microglia may play a role in the damage caused by Alzheimer’s, especially for those who carry two copies a particular gene.

Is your brain aging faster than your chronological age? New research shows it could raise your risk of death and dementia significantly—and offers promise for early intervention.

The Global Neurodegeneration Proteomics Consortium gathered a trove of data on potential signs of neurological disease—and researchers including Knight Initiative director Tony Wyss-Coray are already using it to make new discoveries.

Knight Initiative-funded research ran the gamut from chemistry to public health, but one theme brought it all together: Studying what makes the brain resilient will help more people live better lives.

Knight Initiative researchers developed a blood test that track the biological age of the brain and other organs.

Stanford neurobiologist Carla Shatz, famous for discovering how neural connections develop early in life, is using that knowledge to work on the problem of how they can later deteriorate from Alzheimer’s disease.

A new Stanford study used blood proteins to analyze the 'biological' age of brains and other organs compared to the person's actual age.

The tool, built by a team led by Stanford's Tony Wyss-Coray, uses a single vial of blood to assess the 'biological age' of each organ.