Knight Initiative for Brain Resilience

Neuroradiologist Raag Airan and his lab have found a non-invasive, drug-free method to help clean the brain, reduce inflammation, and treat disease—and with Knight Initiative for Brain Resilience support, they plan to test it in people soon.

The Knight Initiative’s Fall Symposium featured researchers building new molecular atlases of the brain alongside new updates on neurodegenerative disease and what might be done about it.

Amyloid plaques have long been the focus of Alzheimer’s therapies. But Wu Tsai Neuro's Emmanuel Mignot and others are focusing on the stringy tangles of a protein called tau, the unsung second hallmark of Alzheimer’s.

Scientists including Knight Initiative Director Tony Wyss-Coray are trying to find out whether plasma can slow aging.

The genetic variant APOE4, carried by one-fifth of the world’s people, substantially boosts Alzheimer’s risk. But scientists have been puzzled about how to reverse that risk: punch up the gene variant’s potency, or smack it down? Now we know, thanks to research funded by the Knight Initiative for Brain Resilience.

A new study finds links between two popular models of the disease—and the results could change how researchers think about treatment.

Knight Initiative researchers are uncovering the fine points of how our brains learn to move. In the long run, their findings could help devise better treatments for Parkinson's disease.

A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging – shedding light on cognitive decline and diseases like Alzheimer’s, Parkinson’s, and ALS.

Stanford researchers reviewed over 400 therapy evaluations and discovered a crucial mismatch: Mouse studies test disease prevention, while human trials test treatment of existing disease.

Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.