Knight Initiative News

Displaying 21 - 34 news posts of 34

1. NPR This metabolic brain boost revives memory in Alzheimer’s mice

   Study in mice, supported by the Knight Initiative, suggests that an experimental cancer drug boosted brain metabolism, restored memory, and improved Alzheimer's symptoms. This novel approach may offer a new way to treat Alzheimer's beyond targeting amyloid plaques.

   Sep 2 2024

   • Brain aging
   • Clinical / translational research

   

2. Neuroscience News Blocking a Brain Pathway Reverses Memory Loss in Alzheimer’s

   Blocking the kynurenine pathway, a regulator of brain metabolism, can restore cognitive function in lab mice with Alzheimer’s disease. The pathway is overactivated in Alzheimer’s, disrupting glucose metabolism and starving neurons of energy.

   Aug 25 2024

   

3. New York Times New drug approved for early Alzheimer’s

   The drug, Kisunla, made by Eli Lilly, is the latest in a new class of treatments that could modestly slow cognitive decline in initial stages of the disease, but which also carry safety risks according to Knight Initiative for Brain Resilience affiliate Mike Greicius and others.

   Jul 2 2024

   • Brain aging
   • Clinical / translational research

   

4. Nature Alzheimer’s drug with modest benefits wins backing of FDA advisers

   Donanemab slows symptoms of Alzheimer's, but its long-term effects are uncertain. Kathleen Poston, a Knight Initiative steering committee member, emphasizes the need for scientists to obtain data to extrapolate these findings to everyone with AD.

   Jun 11 2024

   

5. Reuters Alzheimer's drug adoption in US slowed by doctors' skepticism

   Wu Tsai Neuro and Knight Initiative for Brain Resilience affiliate, Michael Greicius, and others share their expertise on the limitations of the Alzheimer's drug Leqembi.

   Apr 23 2024

   

6. Everyday Health Talk Show Host Wendy Williams Diagnosed With Dementia and Aphasia

   Wu Tsai Neuro affiliate Sharon Sha shared her expertise on Frontotemporal Dementia amid Wendy Williams' diagnosis.

   Feb 23 2024

   

7. AARP Are Your Organs Aging Faster Than You Are?

   How to know if your organs are ‘older’ than you are, and ways to slow down biological aging according to Knight Initiative director Tony Wyss-Coray and others.

   Jan 26 2024

   

8. Bio IT World Protein Signatures Of Organ Aging Could Aid Disease Prevention Efforts

   Knight Initiative director Tony Wyss-Coray and others are leading the development of a test measuring organ-specific proteins in the blood as a simple and sensible way to estimate biological age.

   Jan 23 2024

   

9. Ground Truths (Eric Topol on Substack) Tony Wyss-Coray: The Science of Aging

   The science to advance our understanding of the aging process—and to potentially slow it down—has made important strides. One of the leading scientists responsible for this work is Professor Tony Wyss-Coray, whose work has focused on brain aging.

   Dec 26 2023

   • Brain aging
   • Clinical / translational research

   

10. Scientific American Your Organs Might Be Aging at Different Rates

    It turns out that your chronological age really is just a number. What’s more important for knowing disease risk is the biological age of each of your organs.

    Dec 6 2023

    

11. STAT News Using AI, scientists create blood test that measures organ aging and predicts disease risk

    In today’s mostly plague- and famine-free world, if you can avoid more modern scourges like gun and car violence, you can expect your death to arrive not with a bang but a whimper; when one of your organs sput-sput-sputters out.

    Dec 6 2023

    

12. Inside Precision Medicine Fixing the Aging Brain

    The number one thing most people fear as they age is developing dementia. As the world’s population becomes increasingly older, this is a growing public health issue too.

    Oct 19 2023

    

13. Genetic Engineering and Biotechnology News Aging Mouse Brain Atlas Reveals White Matter Changes Most Over Time

    A study in mice suggests that the most pronounced changes that occur over time are in the white matter—neurons that are integral to transmitting signals across the brain. The research also examined how two anti-aging treatments—caloric restriction and inf

    Aug 21 2023

    

14. Neuroscience News Is the Brain’s White Matter an Unexpected Key to Aging and Memory?

    Funded in part by the Knight Initiative, researchers at the Wyss-Coray Lab have discovered that age-related cognitive decline is most pronounced in the brain’s white matter in a new study.

    Aug 21 2023