Knight Initiative for Brain Resilience

The number one thing most people fear as they age is developing dementia. As the world’s population becomes increasingly older, this is a growing public health issue too.

Erin Gibson’s lab has discovered that the precursor cells to myelin-producing oligodendrocytes are regulated by the circadian system in mice. When that regulation breaks down, the researchers saw abnormal myelination — but also fragmented sleep.

Working in the Gibson Lab, Brain Resilience Postdoc Scholar Daniela Rojo looks at how abnormal changes in gene activity impact the cells involved in producing myelin to the extent that it leads to neurodegeneration in the brain.

The first Monday of each month, the Knight Initiative for Brain Resilience will host monthly seminars to bring together awardees, affiliated professors and students for a series of 'lab meeting' styled talks. Two speakers will discuss their brain resilience research, experiences in the field, and answer questions about their work.

Oscar Gonzalez, Stanford University

Hypocretin neuron activity reflects sleep pressure

The first Monday of each month, the Knight Initiative for Brain Resilience will host monthly seminars to bring together awardees, affiliated professors and students for a series of 'lab meeting' styled talks. Two speakers will discuss their brain resilience research, experiences in the field, and answer questions about their work.

Sylvie Dobrota, Stanford University

Mitochondrial DNA Sequence Variation and Cognitive Outcomes

The first Monday of each month, the Knight Initiative for Brain Resilience will host monthly seminars to bring together awardees, affiliated professors and students for a series of 'lab meeting' styled talks. Two speakers will discuss their brain resilience research, experiences in the field, and answer questions about their work.

Sanket Gupte, Stanford University

AI methods for automated quantification of organelle phenotyes in CryoET data

In searching for how a gene mutation associated with the cell’s recycling center leads to a rare disease, Knight Initiative for Brain Resilience and Wu Tsai Neuro affiliate Monther Abu-Remaileh and team identified a missing link in neurodegenerative condi

A study in mice suggests that the most pronounced changes that occur over time are in the white matter—neurons that are integral to transmitting signals across the brain. The research also examined how two anti-aging treatments—caloric restriction and inf

Pathologist Siddhartha Jaiswal discovers a surprising twist to our biology: age-related mutations that increase the risk of blood disease also protect against brain disease.

Funded in part by the Knight Initiative, researchers at the Wyss-Coray Lab have discovered that age-related cognitive decline is most pronounced in the brain’s white matter in a new study.