We’re unlocking the mysteries of lifelong brain resilience

Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia.

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Knight Initiative Spring 2026 Symposium
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Preventing Parkinson’s, a new Alzheimer’s drug, and more featured at tenth Knight Initiative Symposium
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Aging brains pile up damaged proteins
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A new atlas could help guide researchers studying neurological disease
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Our collaborative approach to brain resilience research is unlike any institution in the world.

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Brain Resilience Lab

Our research lab blends the innovation of a startup with the academic rigor and support of Stanford University, driving breakthroughs in healthy brain aging.
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Grants & Training Programs

Uniting scientists across disciplines to catalyze bold advances in the science of neurodegeneration, aging, and resilience.
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Resource Hub

Leveraging advanced tools in sequencing, spatial transcriptomics, and proteomics, we’re building a global library of brain aging datasets, empowering researchers to drive their own studies and advance collective knowledge on brain resilience.
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Brain Omics Central

Offering access to advanced omics technologies, including sequencing, spatial, and proteomics, alongside a growing brain tissue repository.

Upcoming Events
Join us to learn about exciting developments in brain resilience research.

Seminar Brain Resilience Seminar: Jordan Moore and Rahul Nagvekar

Apr 6 2026, 12:00 pm – 1:00 pm
Seminar Aging Research Seminar: Vadim Gladyshev

Apr 27 2026, 12:00 pm – 1:00 pm

Knight Initiative News

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BBC Science Focus Just one day in your life could soon reveal how long you'll live

After building a Truman Show experiment, scientists were able to predict the lifespans of their 81 subjects
Mar 18 2026

Brain aging

Discovery science

Behavior and society
Stanford Report Can science slow down aging?

Wu Tsai Neuro affiliate Anne Brunet explores what aging really is, how lifestyle choices might influence longevity, and the promising frontiers of aging research
Mar 18 2026

Brain aging

Aging science

Discovery science
Stanford Medicine Enhancing gut-brain communication reversed cognitive decline and improved memory formation in aging mice

Aging causes changes in gut bacteria in mice, hampering communication between the intestines and the brain—but restoring this connection helped old mice form memories as well as young animals.
Mar 13 2026

Brain aging

Discovery science

Circuits and systems

Featured Projects

Innovation Awards | 2022 Mutant microglia and resilience to Alzheimer’s disease
Funded Researcher(s)

Siddhartha Jaiswal

Marius Wernig

Jody Elizabeth Hooper

Caleb Lareau
Research Keywords

Brain resilience

Discovery science
Innovation Awards | 2022 Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience
Funded Researcher(s)

Jonathan Z. Long

Thomas Montine, MD, PhD

Steven Banik
Research Keywords

Brain resilience

Discovery science

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