Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
The database of lysosomal proteins is already helping researchers study how brain cells’ waste and recycling systems work—or don’t—in Alzheimer’s and other neurological diseases
From studying post-viral fatigue to engineering transparent mouse brains, round three of the Wu Tsai Neurosciences Institute’s Big Ideas grants will push the bounds of what’s possible
Join us as we look back on some of the key studies we covered here at Wu Tsai Neuro and the Knight Initiative in 2025 to give a (very partial) overview of the impact of our community’s research efforts this past year
Amyotrophic lateral sclerosis and frontotemporal dementia are devastating neurodegenerative diseases. Knight Initiative postdoc Yi Zeng is working to understand the role a central protein plays in both diseases—and whether it might point toward new diagnostics and treatments
Research from Knight Initiative Director Tony Wyss-Coray's lab show that an Alzheimer's hallmark—myriad oily droplets in brain cells called microglia—may help connect several of the disorder’s better known but not well understood features.
Neurons are built to last, but with age, bad things can happen to them. Wu Tsai Neuro affiliate Katrin Andreasson's work shows a lot of it is triggered by what’s happening to immune cells outside of the brain.
Amyloid plaques have long been the focus of Alzheimer’s therapies. But Wu Tsai Neuro's Emmanuel Mignot and others are focusing on the stringy tangles of a protein called tau, the unsung second hallmark of Alzheimer’s.
Knight Initiative researchers are uncovering the fine points of how our brains learn to move. In the long run, their findings could help devise better treatments for Parkinson's disease.
