The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.
The Global Neurodegeneration Proteomics Consortium gathered a trove of data on potential signs of neurological disease—and researchers including Knight Initiative director Tony Wyss-Coray are already using it to make new discoveries.
A blood-test analysis developed at Stanford Medicine can determine the “biological ages” of 11 separate organ systems in individuals’ bodies and predict the health consequences.
Research from the Giocomo lab finds that mice create neural maps of the location of rewards, distinct from the well-known hippocampal maps of an animal's location in space.
Improving cells’ ability to sort and recycle components—including cholesterol—could lead to therapies for a wide range of neurodegenerative conditions.
A new analysis of a vaccination program in Wales by a Knight Initiative–supported team found that the shingles vaccine appeared to lower new dementia diagnoses by 20% — more than any other known intervention.
New findings about the sugary armor on the brain’s frontline cells could shed light on cognitive decline and diseases like Alzheimer’s—and open new avenues for treatment.
What if forgetfulness didn't ahve to be a part of aging? Now, discoveries about the impact of glucose in mouse brains by Knight Initiative affiliate, Anne Brunet, and team suggest routes for eliciting new neuron growth in old brains.
Researchers at Stanford’s Knight Initiative for Brain Resilience merge spatial transcriptomics and AI to uncover how local cellular interactions drive brain aging and resilience
With Knight Initiative support, Stanford researchers uncover a biochemical “off-ramp” in ketosis, rewriting our understanding of how ketosis influences metabolism.
A team of neuroscientists at the Knight Initiative for Brain Resilience have zeroed in on a critical regulator of brain metabolism that may be over-activated in the brains of patients with Alzheimer’s disease.
Groundbreaking research supported by the Knight Initiative for Brain Resilience at Stanford’s Wu Tsai Neurosciences Institute deepens our understanding of how the amino acid taurine may help reduce appetite and prevent obesity.
Most Parkinson’s disease patients struggle with speech problems. New research by Stanford Medicine scientists uncovers the brain connections that could be essential to preserving speech.
Pro-inflammatory protein TREM1 in peripheral immune cells may promote age-related cognitive decline and dementia, according to Knight Initiative–funded research.
Recent research supported by the Knight Initiative has identified a link between lipid droplets in the microglia to a known genetic risk factor for AD.
Two new studies supported by the Knight Initiative highlight groundbreaking new early biomarkers for the diagnosis and treatment of neurodegenerative disease.
Research supported by the Knight Initiative found that metformin, a commonly prescribed diabetes drug associated with moderate weight loss, stimulates the production of lac-phe, a molecule abundant after exercise.
