We’re unlocking the mysteries of lifelong brain resilience

Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia.

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Knight Initiative Spring 2026 Symposium
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A new atlas could help guide researchers studying neurological disease
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Building bridges between Alzheimer’s theories
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Rethinking how we learn to move in the world
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Our collaborative approach to brain resilience research is unlike any institution in the world.

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Brain Resilience Lab

Our research lab blends the innovation of a startup with the academic rigor and support of Stanford University, driving breakthroughs in healthy brain aging.
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Grants & Training Programs

Uniting scientists across disciplines to catalyze bold advances in the science of neurodegeneration, aging, and resilience.
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Resource Hub

Leveraging advanced tools in sequencing, spatial transcriptomics, and proteomics, we’re building a global library of brain aging datasets, empowering researchers to drive their own studies and advance collective knowledge on brain resilience.
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Brain Omics Central

Offering access to advanced omics technologies, including sequencing, spatial, and proteomics, alongside a growing brain tissue repository.

Upcoming Events
Join us to learn about exciting developments in brain resilience research.

Seminar Brain Resilience Seminar: Meena Chakraborty and Julian Garcia

Mar 2 2026, 12:00 pm – 1:00 pm
Seminar Brain Resilience Seminar: Jordan Moore and Rahul Nagvekar

Apr 6 2026, 12:00 pm – 1:00 pm

Knight Initiative News

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Podcast episodes Why do our minds wander? What the brain's default mode tells us about our humanity

We speak with cognitive scientist Vinod Menon about the brain networks behind day dreaming, rumination, and our sense of self
Feb 12 2026

Brain function

Circuits and systems

Discovery science
The Transmitter Aging neurons outsource garbage disposal, clog microglia

Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Feb 10 2026

Brain aging

Discovery science

Molecules and cells
Research news Aging brains pile up damaged proteins

Proteins that start life inside neurons build up faster in old age and spread to other brain cells—a potential source of neurological mischief
Feb 2 2026

Brain aging

Brain resilience

Molecules and cells

Featured Projects

Innovation Awards | 2022 Mutant microglia and resilience to Alzheimer’s disease
Lead Researcher(s)

Siddhartha Jaiswal
Team Members

Marius Wernig

Jody Elizabeth Hooper

Caleb Lareau
Research Keywords

Brain resilience

Discovery science
Innovation Awards | 2022 Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience
Lead Researcher(s)

Jonathan Z. Long
Team Members

Thomas Montine, MD, PhD

Steven Banik
Research Keywords

Brain resilience

Discovery science

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