We’re unlocking the mysteries of lifelong brain resilience

Through bold and innovative approaches, we’re decoding how brains stay healthy as we age and driving a future free from dementia.

Featured 01 / 04

Knight Initiative Spring 2026 Symposium
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Preventing Parkinson’s, a new Alzheimer’s drug, and more featured at tenth Knight Initiative Symposium
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Aging brains pile up damaged proteins
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A new atlas could help guide researchers studying neurological disease
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Our collaborative approach to brain resilience research is unlike any institution in the world.

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Brain Resilience Lab

Our research lab blends the innovation of a startup with the academic rigor and support of Stanford University, driving breakthroughs in healthy brain aging.
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Grants & Training Programs

Uniting scientists across disciplines to catalyze bold advances in the science of neurodegeneration, aging, and resilience.
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Resource Hub

Leveraging advanced tools in sequencing, spatial transcriptomics, and proteomics, we’re building a global library of brain aging datasets, empowering researchers to drive their own studies and advance collective knowledge on brain resilience.
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Brain Omics Central

Offering access to advanced omics technologies, including sequencing, spatial, and proteomics, alongside a growing brain tissue repository.

Upcoming Events
Join us to learn about exciting developments in brain resilience research.

Seminar Brain Resilience Seminar: Jordan Moore and Rahul Nagvekar

Apr 6 2026, 12:00 pm – 1:00 pm
Seminar Aging Research Seminar: Vadim Gladyshev

Apr 27 2026, 12:00 pm – 1:00 pm

Knight Initiative News

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Stanford Medicine Enhancing gut-brain communication reversed cognitive decline and improved memory formation in aging mice

Aging causes changes in gut bacteria in mice, hampering communication between the intestines and the brain—but restoring this connection helped old mice form memories as well as young animals.
Mar 13 2026

Brain aging

Discovery science

Circuits and systems
Research news Watching a lifetime in motion reveals the architecture of aging

Knight Initiative scientists tracked every moment of the life of the African turquoise killifish, showing that behavior alone can forecast whether an animal will live a long or short life
Mar 12 2026

Brain aging

Discovery science

Behavior and society
Pershing Square Foundation Wu Tsai Neuro and Knight Initiative researchers awarded MIND Prizes

The Maximizing Innovation in Neuroscience Discovery Prizes will give Faculty Scholar Guosong Hong and Knight Initiative-supported researcher Pascal Geldsetzer $750,000 each over three years to develop research on neurodegenerative diseases.
Mar 10 2026

Brain aging

Technology development

Discovery science

Featured Projects

Innovation Awards | 2022 Mutant microglia and resilience to Alzheimer’s disease
Funded Researcher(s)

Siddhartha Jaiswal

Marius Wernig

Jody Elizabeth Hooper

Caleb Lareau
Research Keywords

Brain resilience

Discovery science
Innovation Awards | 2022 Mechanistic dissection and therapeutic capture of an exercise-inducible metabolite signaling pathway for brain resilience
Funded Researcher(s)

Jonathan Z. Long

Thomas Montine, MD, PhD

Steven Banik
Research Keywords

Brain resilience

Discovery science

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