A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging – shedding light on cognitive decline and diseases like Alzheimer’s, Parkinson’s, and ALS.
Knight Initiative researchers used a new lab model of aging human neurons to show that as cells age, lysosomes fall into disrepair and waste builds up—feeding a damaging cycle that could lead to Alzheimer’s.
Blood and cerebrospinal fluid markers tied to inflammation and metabolism sort some patients into subgroups, according to Knight Initiative researchers, a step toward predicting progression and tailoring care.
The technique, which used genetically healthy donor cells, prolonged life and function in mice with a disease similar to Tay-Sachs. It may help with other neurodegenerative diseases like Alzheimer’s.
The lab’s second crop of pilot awards will foster research in visual attention, the neurophysiology of exercise, and therapies for autism and mild cognitive impairment associated with aging.
Andreasson received the Inge Grundke-Iqbal Award for her work on restoring cognition in Alzheimer's. Karly Cody, a postdoctoral fellow in the lab of Knight Initiative researcher Elizabeth Mormino, was also honored.
Is your brain aging faster than your chronological age? New research shows it could raise your risk of death and dementia significantly—and offers promise for early intervention.
Knight Initiative-funded research ran the gamut from chemistry to public health, but one theme brought it all together: Studying what makes the brain resilient will help more people live better lives.
The findings of two recent studies give hope that the disease could one day be reversed in humans—but experts warn that this complex disease will likely need multiple complementary treatments.
A blood-test analysis developed at Stanford Medicine can determine the “biological ages” of 11 separate organ systems in individuals’ bodies and predict the health consequences.
A decade ago, three generations of Stanford scientists banded together to publish a landmark study on one of the brain’s most prevalent structures. Today, Wu Tsai Neurosciences Institute researchers are discovering that myelin is key to just about every aspect of neurological health.
Research from the Giocomo lab finds that mice create neural maps of the location of rewards, distinct from the well-known hippocampal maps of an animal's location in space.
New findings about the sugary armor on the brain’s frontline cells could shed light on cognitive decline and diseases like Alzheimer’s—and open new avenues for treatment.
Researchers at Stanford’s Knight Initiative for Brain Resilience merge spatial transcriptomics and AI to uncover how local cellular interactions drive brain aging and resilience
